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1.

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4⁺ T Cells in COVID-19.

Meckiff, Benjamin J; Ramírez-Suástegui, Ciro; Fajardo, Vicente; Chee, Serena J; Kusnadi, Anthony; Simon, Hayley; Eschweiler, Simon; Grifoni, Alba; Pelosi, Emanuela; Weiskopf, Daniela; Sette, Alessandro; Ay, Ferhat; Seumois, Grégory; Ottensmeier, Christian H; Vijayanand, Pandurangan.

Cell ; 183(5): 1340-1353.e16, 2020 11 25.

Artículo en Inglés | MEDLINE | ID: mdl-33096020

2.

Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy.

Eschweiler, Simon; Clarke, James; Ramírez-Suástegui, Ciro; Panwar, Bharat; Madrigal, Ariel; Chee, Serena J; Karydis, Ioannis; Woo, Edwin; Alzetani, Aiman; Elsheikh, Somaia; Hanley, C J; Thomas, G J; Friedmann, Peter S; Sanchez-Elsner, Tilman; Ay, Ferhat; Ottensmeier, Christian H; Vijayanand, Pandurangan.

Nat Immunol ; 22(8): 1052-1063, 2021 08.

Artículo en Inglés | MEDLINE | ID: mdl-34168370

3.

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.

Ganesan, Anusha-Preethi; Clarke, James; Wood, Oliver; Garrido-Martin, Eva M; Chee, Serena J; Mellows, Toby; Samaniego-Castruita, Daniela; Singh, Divya; Seumois, Grégory; Alzetani, Aiman; Woo, Edwin; Friedmann, Peter S; King, Emma V; Thomas, Gareth J; Sanchez-Elsner, Tilman; Vijayanand, Pandurangan; Ottensmeier, Christian H.

Nat Immunol ; 18(8): 940-950, 2017 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-28628092

4.

Intermittent PI3KÎ´ inhibition sustains anti-tumour immunity and curbs irAEs.

Eschweiler, Simon; Ramírez-Suástegui, Ciro; Li, Yingcong; King, Emma; Chudley, Lindsey; Thomas, Jaya; Wood, Oliver; von Witzleben, Adrian; Jeffrey, Danielle; McCann, Katy; Simon, Hayley; Mondal, Monalisa; Wang, Alice; Dicker, Martina; Lopez-Guadamillas, Elena; Chou, Ting-Fang; Dobbs, Nicola A; Essame, Louisa; Acton, Gary; Kelly, Fiona; Halbert, Gavin; Sacco, Joseph J; Schache, Andrew Graeme; Shaw, Richard; McCaul, James Anthony; Paterson, Claire; Davies, Joseph H; Brennan, Peter A; Singh, Rabindra P; Loadman, Paul M; Wilson, William; Hackshaw, Allan; Seumois, Gregory; Okkenhaug, Klaus; Thomas, Gareth J; Jones, Terry M; Ay, Ferhat; Friberg, Greg; Kronenberg, Mitchell; Vanhaesebroeck, Bart; Vijayanand, Pandurangan; Ottensmeier, Christian H.

Nature ; 605(7911): 741-746, 2022 05.

Artículo en Inglés | MEDLINE | ID: mdl-35508656

5.

Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma.

Hilf, Norbert; Kuttruff-Coqui, Sabrina; Frenzel, Katrin; Bukur, Valesca; Stevanovic, Stefan; Gouttefangeas, Cecile; Platten, Michael; Tabatabai, Ghazaleh; Dutoit, Valerie; van der Burg, Sjoerd H; Straten, Per Thor; Martinez-Ricarte, Francisco; Ponsati, Berta; Okada, Hideho; Lassen, Ulrik; Admon, Arie; Ottensmeier, Christian H; Ulges, Alexander; Kreiter, Sebastian; von Deimling, Andreas; Skardelly, Marco; Migliorini, Denis; Kroep, Judith R; Idorn, Manja; Rodon, Jordi; Piro, Jordi; Poulsen, Hans S; Shraibman, Bracha; McCann, Katy; Mendrzyk, Regina; Lower, Martin; Stieglbauer, Monika; Britten, Cedrik M; Capper, David; Welters, Marij J P; Sahuquillo, Juan; Kiesel, Katharina; Derhovanessian, Evelyna; Rusch, Elisa; Bunse, Lukas; Song, Colette; Heesch, Sandra; Wagner, Claudia; Kemmer-Bruck, Alexandra; Ludwig, Jorg; Castle, John C; Schoor, Oliver; Tadmor, Arbel D; Green, Edward; Fritsche, Jens.

Nature ; 566(7745): E13, 2019 02.

Artículo en Inglés | MEDLINE | ID: mdl-30733620

6.

Actively personalized vaccination trial for newly diagnosed glioblastoma.

Hilf, Norbert; Kuttruff-Coqui, Sabrina; Frenzel, Katrin; Bukur, Valesca; Stevanovic, Stefan; Gouttefangeas, Cécile; Platten, Michael; Tabatabai, Ghazaleh; Dutoit, Valerie; van der Burg, Sjoerd H; Thor Straten, Per; Martínez-Ricarte, Francisco; Ponsati, Berta; Okada, Hideho; Lassen, Ulrik; Admon, Arie; Ottensmeier, Christian H; Ulges, Alexander; Kreiter, Sebastian; von Deimling, Andreas; Skardelly, Marco; Migliorini, Denis; Kroep, Judith R; Idorn, Manja; Rodon, Jordi; Piró, Jordi; Poulsen, Hans S; Shraibman, Bracha; McCann, Katy; Mendrzyk, Regina; Löwer, Martin; Stieglbauer, Monika; Britten, Cedrik M; Capper, David; Welters, Marij J P; Sahuquillo, Juan; Kiesel, Katharina; Derhovanessian, Evelyna; Rusch, Elisa; Bunse, Lukas; Song, Colette; Heesch, Sandra; Wagner, Claudia; Kemmer-Brück, Alexandra; Ludwig, Jörg; Castle, John C; Schoor, Oliver; Tadmor, Arbel D; Green, Edward; Fritsche, Jens.

Nature ; 565(7738): 240-245, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30568303

7.

Efficacy and Safety of the Melphalan/Hepatic Delivery System in Patients with Unresectable Metastatic Uveal Melanoma: Results from an Open-Label, Single-Arm, Multicenter Phase 3 Study.

Zager, Jonathan S; Orloff, Marlana; Ferrucci, Pier Francesco; Choi, Junsung; Eschelman, David J; Glazer, Evan S; Ejaz, Aslam; Howard, J Harrison; Richtig, Erika; Ochsenreither, Sebastian; Reddy, Sunil A; Lowe, Michael C; Beasley, Georgia M; Gesierich, Anja; Bender, Armin; Gschnell, Martin; Dummer, Reinhard; Rivoire, Michel; Arance, Ana; Fenwick, Stephen William; Sacco, Joseph J; Haferkamp, Sebastian; Weishaupt, Carsten; John, Johnny; Wheater, Matthew; Ottensmeier, Christian H.

Ann Surg Oncol ; 2024 May 04.

Artículo en Inglés | MEDLINE | ID: mdl-38704501

8.

CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer.

Hardwick, Marc; Nolan, Luke; Nicoll, James A R; Jogai, Sanjay; Arriola, Edurne; Joseph-Pietras, Debora; Norman, Jeanette; Ottensmeier, Christian H H; Galea, Ian.

Neuropathol Appl Neurobiol ; 48(2): e12755, 2022 02.

Artículo en Inglés | MEDLINE | ID: mdl-34309064

9.

Analysis of Immune Landscape in Pancreatic and Ileal Neuroendocrine Tumours Demonstrates an Immune Cold Tumour Microenvironment.

Tanno, Lulu; Naheed, Salma; Dunbar, Jonathan; Tod, Jo; Lopez, Maria A; Taylor, Julian; Machado, Maria; Green, Bryan; Ashton-Key, Margaret; Chee, Serena J; Wood, Oliver; Pearce, Neil W; Thomas, Gareth J; Friedmann, Peter S; Cave, Judith; Ottensmeier, Christian H.

Neuroendocrinology ; 112(4): 370-383, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-34157710

10.

Prospective longitudinal study of immune checkpoint molecule (ICM) expression in immune cell subsets during curative conventional therapy of head and neck squamous cell carcinoma (HNSCC).

von Witzleben, Adrian; Fehn, Adrian; Grages, Ayla; Ezic, Jasmin; Jeske, Sandra S; Puntigam, Lisa K; Brunner, Cornelia; Kraus, Johann M; Kestler, Hans A; Doescher, Johannes; Brand, Matthias; Theodoraki, Marie-Nicole; Ottensmeier, Christian H; Hoffmann, Thomas K; Schuler, Patrick J; Laban, Simon.

Int J Cancer ; 148(8): 2023-2035, 2021 04 15.

Artículo en Inglés | MEDLINE | ID: mdl-33336372

11.

HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma.

Fleming, Jason C; Woo, Jeongmin; Moutasim, Karwan; Mellone, Massimiliano; Frampton, Steven J; Mead, Abbie; Ahmed, Waseem; Wood, Oliver; Robinson, Hollie; Ward, Matthew; Woelk, Christopher H; Ottensmeier, Christian H; King, Emma; Kim, Dae; Blaydes, Jeremy P; Thomas, Gareth J.

Br J Cancer ; 120(3): 356-367, 2019 02.

Artículo en Inglés | MEDLINE | ID: mdl-30655616

12.

Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model.

Allen, Alex; Wang, Chuan; Caproni, Lisa J; Sugiyarto, Gessa; Harden, Elena; Douglas, Leon R; Duriez, Patrick J; Karbowniczek, Kinga; Extance, Jon; Rothwell, Paul J; Orefo, Ifeayinwa; Tite, John P; Stevenson, Freda K; Ottensmeier, Christian H; Savelyeva, Natalia.

Cancer Immunol Immunother ; 67(4): 627-638, 2018 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-29330557

13.

Patient selection for anti-PD-1/PD-L1 therapy in advanced non-small-cell lung cancer: implications for clinical practice.

Califano, Raffaele; Lal, Rohit; Lewanski, Conrad; Nicolson, Marianne C; Ottensmeier, Christian H; Popat, Sanjay; Hodgson, Matthew; Postmus, Pieter E.

Future Oncol ; 14(23): 2415-2431, 2018 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-29978725

14.

Evaluating the effect of immune cells on the outcome of patients with mesothelioma.

Chee, Serena J; Lopez, Maria; Mellows, Toby; Gankande, Sharmali; Moutasim, Karwan A; Harris, Scott; Clarke, James; Vijayanand, Pandurangan; Thomas, Gareth J; Ottensmeier, Christian H.

Br J Cancer ; 117(9): 1341-1348, 2017 Oct 24.

Artículo en Inglés | MEDLINE | ID: mdl-28817839

15.

Novel players: tissue-resident memory B cells.

Savelyeva, Natalia; Ottensmeier, Christian H.

Blood ; 136(24): 2722-2723, 2020 12 10.

Artículo en Inglés | MEDLINE | ID: mdl-33301032

16.

Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma.

Noble, Fergus; Mellows, Toby; McCormick Matthews, Leo H; Bateman, Adrian C; Harris, Scott; Underwood, Timothy J; Byrne, James P; Bailey, Ian S; Sharland, Donna M; Kelly, Jamie J; Primrose, John N; Sahota, Surinder S; Bateman, Andrew R; Thomas, Gareth J; Ottensmeier, Christian H.

Cancer Immunol Immunother ; 65(6): 651-62, 2016 06.

Artículo en Inglés | MEDLINE | ID: mdl-27020682

17.

Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study.

McCann, Katy J; Godeseth, Rosemary; Chudley, Lindsey; Mander, Ann; Di Genova, Gianfranco; Lloyd-Evans, Paul; Kerr, Jonathan P; Malykh, Vladimir B; Jenner, Matthew W; Orchard, Kim H; Stevenson, Freda K; Ottensmeier, Christian H.

Cancer Immunol Immunother ; 64(8): 1021-32, 2015 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-25982371

18.

Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function.

Moutasim, Karwan A; Mellows, Toby; Mellone, Massimiliano; Lopez, Marie-Antoinette; Tod, Joanne; Kiely, Philip C; Sapienza, Karen; Greco, Azzura; Neill, Graham W; Violette, Shelia; Weinreb, Paul H; Marshall, John F; Ottensmeier, Christian H; Sayan, A Emre; Jenei, Veronika; Thomas, Gareth J.

J Pathol ; 233(2): 196-208, 2014 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-24573955

19.

Harmonisation of short-term in vitro culture for the expansion of antigen-specific CD8(+) T cells with detection by ELISPOT and HLA-multimer staining.

Chudley, Lindsey; McCann, Katy J; Coleman, Adam; Cazaly, Angelica M; Bidmon, Nicole; Britten, Cedrik M; van der Burg, Sjoerd H; Gouttefangeas, Cecile; Jandus, Camilla; Laske, Karoline; Maurer, Dominik; Romero, Pedro; Schröder, Helene; Stynenbosch, Linda F M; Walter, Steffen; Welters, Marij J P; Ottensmeier, Christian H.

Cancer Immunol Immunother ; 63(11): 1199-211, 2014 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-25134947

20.

Implications of Tuberculosis Reactivation after Immune Checkpoint Inhibition.

Elkington, Paul T; Bateman, Adrian C; Thomas, Gareth J; Ottensmeier, Christian H.

Am J Respir Crit Care Med ; 198(11): 1451-1453, 2018 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-30141960

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